Klei T R, Crowell W A
J Helminthol. 1981 Jun;55(2):123-31.
The major organs, other than lymphatics, of jirds (Meriones unguiculatus) with prepatent and chronic patent infections of Brugia pahangi were studied by standard histological, electron microscopical and fluorescent antibody techniques. Changes observed and not previously described in detail or in large numbers of animals are reported. Multifocal non-suppurative interstitial nephritis was observed in 4% on animals with patent infections of 163 days duration and in 69% of animals with patent infections of 274 days duration. Glomerular changes were not observed in kidneys of any animals infected with B. pahangi. The occurrence of large granulomata composed of lymphocytes, macrophages, eosinophils and giant cells in the liver and smaller granulomata in the spleen correlated with patency of infections but microfilariae or worm antigens were not observed in these areas. Amyloid deposits were demonstrated in the spleen of 4% of animals with patent infections of 163 days duration and in 38% of animals with patent infections of 274 days duration but were not seen in uninfected animals of the same age or animals receiving only challenge inoculations of 28 days duration.
采用标准组织学、电子显微镜和荧光抗体技术，对感染帕氏布鲁线虫处于潜伏期和慢性感染期的肥尾沙鼠（Meriones unguiculatus）除淋巴管外的主要器官进行了研究。报告了所观察到的此前未在大量动物中详细描述的变化。在感染163天处于感染期的动物中，4%出现多灶性非化脓性间质性肾炎；在感染274天处于感染期的动物中，69%出现该病症。感染帕氏布鲁线虫的所有动物的肾脏均未观察到肾小球变化。肝脏中出现由淋巴细胞、巨噬细胞、嗜酸性粒细胞和巨细胞组成的大型肉芽肿，脾脏中出现较小的肉芽肿，这与感染的持续时间相关，但在这些区域未观察到微丝蚴或蠕虫抗原。在感染163天处于感染期的动物中，4%的脾脏出现淀粉样沉积物；在感染274天处于感染期的动物中，38%出现该沉积物，但在相同年龄的未感染动物或仅接受28天激发接种的动物中未见到。
