人多形核中性粒细胞对威克汉姆原藻的吞噬作用和杀藻活性。
Phagocytosis and algicidal activity of human polymorphonuclear neutrophils against Prototheca wickerhamii.
作者信息
Phair J P, Williams J E, Bassaris H P, Zeiss C R, Morlock B A
出版信息
J Infect Dis. 1981 Jul;144(1):72-7. doi: 10.1093/infdis/144.1.72.
Protothecosis is an uncommon infection due to Prototheca wickerhamii. Recently, a patient with progressive cutaneous protothecosis and an apparent defect in the ability of her polymorphonuclear neutrophils (PMNs) to kill P. wickerhamii was successfully treated. Therefore, the role of PMNs and serum opsonins in host defense against tissue invasion by this organism was evaluated. The results show that human PMNs ingested and kill P. wickerhamii. Ultrastructural studies revealed digestion of the organism by PMNs 60 min after ingestion. Optimal phagocytosis and killing of P. wickerhamii by PMNs required the presence of both specific IgG antibody and heat-labile opsonins.
原藻病是由威克汉姆原藻引起的一种罕见感染。最近，一名患有进行性皮肤原藻病且其多形核中性粒细胞（PMN）杀灭威克汉姆原藻能力明显缺陷的患者得到了成功治疗。因此，对PMN和血清调理素在宿主抵御该生物体组织侵袭中的作用进行了评估。结果表明，人类PMN可摄取并杀灭威克汉姆原藻。超微结构研究显示，摄取后60分钟PMN对该生物体进行了消化。PMN对威克汉姆原藻的最佳吞噬和杀灭需要特异性IgG抗体和热不稳定调理素的共同存在。
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