Iyengar G V
J Pathol. 1981 Jul;134(3):173-80. doi: 10.1002/path.1711340302.
The implication of post-mortem changes such as cell swelling, imbibition and autolysis on the elemental composition of body organs has been studied in rats. Liver has been chosen as an example. Retaining the liver inside the intact dead body for different periods of time at ambient temperature induced significant changes in its weight due to post-mortem tissue degeneration. Livers from animals that were frozen at -15 degrees C also showed significant decreases in weight when they were thawed on the third day. The effect of these changes on the concentrations of various elements depended on the association of the elements with extracellular fluid and intracellular components. For example, concentration of K+ was affected more by the lysis of the cell and sustained losses up to 30 per cent. in relation to the control values, while the total content was reduced by more than 40 per cent. as a result of both lysis and tissue liquefaction. For Na+, differences ranging from +10 to -20 per cent. in concentrations and +20 to -40 per cent. in total content were observed which could be explained by the movement of fluid in and out of the organ. Among trace elements, variation observed for iron ranged from -20 to +40 per cent., while both copper and zinc were found to fluctuate between -20 and +20 per cent. The loss observed in the total content in the liver for the five trace elements studied (Cu, Fe, Mn, Rb and Zn) was found to be about 20 to 40 per cent.
在大鼠身上研究了诸如细胞肿胀、吸胀和自溶等死后变化对身体器官元素组成的影响。以肝脏为例。在环境温度下将肝脏保留在完整的尸体中不同时间段，由于死后组织退化，其重量发生了显著变化。在-15摄氏度下冷冻的动物肝脏在第三天解冻时重量也显著下降。这些变化对各种元素浓度的影响取决于元素与细胞外液和细胞内成分的关联。例如，K+的浓度受细胞裂解影响更大，相对于对照值持续损失高达30%，而由于裂解和组织液化，其总量减少了40%以上。对于Na+，观察到浓度差异在+10%至-20%之间，总量差异在+20%至-40%之间，这可以通过液体进出器官的移动来解释。在微量元素中，铁的变化范围为-20%至+40%，而铜和锌的波动范围在-20%至+20%之间。在所研究的五种微量元素（铜、铁、锰、铷和锌）中，肝脏中总量的损失约为20%至40%。
