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慢性酒精使用者的染色体损伤。

Chromosomal damage in chronic alcohol users.

作者信息

Obe G, Herha J

出版信息

Humangenetik. 1975 Sep 23;29(3):191-200. doi: 10.1007/BF00297623.

DOI:10.1007/BF00297623
PMID:1165099
Abstract

First in vitro mitoses were analysed from the peripheral leukocytes of 22 chronic alcohol users and of 18 controls. The frequency of exchange aberrations of the chromatid and chromosome type were significantly higher in the alcohol as compared with the control group. The results indicate an indirect or direct mutagenic activity of alcohol in vivo.

摘要

首先对22名慢性酒精使用者和18名对照者的外周血白细胞进行体外有丝分裂分析。与对照组相比，酒精组染色单体和染色体型交换畸变的频率显著更高。结果表明酒精在体内具有间接或直接的诱变活性。

相似文献

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Chromosomal damage in chronic alcohol users.慢性酒精使用者的染色体损伤。
Humangenetik. 1975 Sep 23;29(3):191-200. doi: 10.1007/BF00297623.
2
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引用本文的文献

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Increased frequency of sister-chromatid exchanges in alcoholics.酗酒者姐妹染色单体交换频率增加。
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Methods for analysis of the mutagenicity of indirect mutagens/carcinogens in eukaryotic cells.真核细胞中间接诱变剂/致癌物诱变性的分析方法。
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Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay.

本文引用的文献

1
Toxicological and pharmacological properties of clomethiazole.氯美噻唑的毒理学和药理学特性。
Acta Psychiatr Scand Suppl. 1966;192:15-22. doi: 10.1111/j.1600-0447.1966.tb08812.x.
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Chromosomal abnormalities in ascitic fluid from patients with alcoholic cirrhosis.酒精性肝硬化患者腹水中的染色体异常。
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Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.接受卡马西平和苯妥英单药治疗的癫痫患者的染色体损伤。
Hum Genet. 1976 Dec 15;34(3):255-63. doi: 10.1007/BF00295288.
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Hum Genet. 1978 Sep 19;43(3):329-31. doi: 10.1007/BF00278841.
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Premature chromosome condensation in a case of Fanconi's anemia.
Humangenetik. 1975 Jun 19;28(2):159-62. doi: 10.1007/BF00735749.
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Induction of dominant lethal mutation in male mice by ethyl alcohol.乙醇对雄性小鼠显性致死突变的诱导作用。
Nature. 1975 Jan 10;253(5487):134-6. doi: 10.1038/253134a0.
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Premature chromosme condensation in the bone marrow of Chinese hamster after application of bleomycin in vivo.
Mutat Res. 1975 Feb;27(2):285-94. doi: 10.1016/0027-5107(75)90089-5.
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The human leukocyte test system. III. Premature chromosome condensation from chemically and x-ray induced micronuclei.
Mutat Res. 1975 Jan;27(1):89-101.