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Induction of chromosomal aberrations in peripheral lymphocytes of human blood in vitro, and of SCEs in bone-marrow cells of mice in vivo by ethanol and its metabolite acetaldehyde.

作者信息

Obe G, Natarajan A T, Meyers M, Hertog A D

出版信息

Mutat Res. 1979 Nov;68(3):291-4. doi: 10.1016/0165-1218(79)90160-5.

DOI:10.1016/0165-1218(79)90160-5
PMID:514307
Abstract
摘要

相似文献

1
Induction of chromosomal aberrations in peripheral lymphocytes of human blood in vitro, and of SCEs in bone-marrow cells of mice in vivo by ethanol and its metabolite acetaldehyde.乙醇及其代谢产物乙醛在体外诱导人外周血淋巴细胞染色体畸变，在体内诱导小鼠骨髓细胞姐妹染色单体交换。
Mutat Res. 1979 Nov;68(3):291-4. doi: 10.1016/0165-1218(79)90160-5.
2
The frequency of sister chromatid exchanges in human lymphocytes treated with ethanol and acetaldehyde.乙醇和乙醛处理的人淋巴细胞中姐妹染色单体交换的频率。
Hereditas. 1982;97(2):301-3. doi: 10.1111/j.1601-5223.1982.tb00774.x.
3
[Comparison of the levels of chromosome aberration and sister chromatid exchange induced by chemical mutagens in vitro].[化学诱变剂体外诱导染色体畸变和姐妹染色单体交换水平的比较]
Biull Eksp Biol Med. 1983 Nov;96(11):93-5.
4
Sister chromatid exchange in vivo in mice: I. The influence of increasing doses of bromodeoxyuridine.
Environ Mutagen. 1980;2(1):35-42. doi: 10.1002/em.2860020106.
5
Cytogenetic effects of inhaled benzene in murine bone marrow: induction of sister chromatid exchanges, chromosomal aberrations, and cellular proliferation inhibition in DBA/2 mice.吸入苯对小鼠骨髓的细胞遗传学效应：DBA/2小鼠中姐妹染色单体交换、染色体畸变的诱导及细胞增殖抑制
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2148-52. doi: 10.1073/pnas.77.4.2148.
6
Chromosomal aberrations and sister-chromatid exchanges in workers exposed to styrene.接触苯乙烯的工人的染色体畸变和姐妹染色单体交换
Mutat Res. 1983 Mar;119(3):361-9. doi: 10.1016/0165-7992(83)90186-0.
7
Trenimon-induced SCEs and structural chromosomal aberrations in early- and late-dividing lymphocytes.曲尼莫引起的早、晚期分裂淋巴细胞中的姐妹染色单体交换（SCEs）和染色体结构畸变。
Mutat Res. 1980 Nov;73(1):125-31. doi: 10.1016/0027-5107(80)90141-4.
8
Bleomycin-induced chromosomal aberrations and sister chromatid exchanges in Down lymphocyte cultures.博来霉素诱导唐氏淋巴细胞培养物中的染色体畸变和姐妹染色单体交换。
Hum Genet. 1984;66(1):57-61. doi: 10.1007/BF00275187.
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Effect of monosubstituted epoxides on chromosome aberrations and SCE in cultured human lymphocytes.
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Chromosomal effects of sodium selenite in vivo. III. Aberrations and sister chromatid exchanges in Chinese hamster bone marrow.亚硒酸钠在体内的染色体效应。III. 中国仓鼠骨髓中的畸变和姐妹染色单体交换
Hereditas. 1980;93(1):101-5.

引用本文的文献

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Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.乙醛介导的鳞状上皮细胞致癌作用的分子机制
Int J Mol Sci. 2017 Sep 10;18(9):1943. doi: 10.3390/ijms18091943.
2
Hypersensitivities for acetaldehyde and other agents among cancer cells null for clinically relevant Fanconi anemia genes.在临床上相关的范可尼贫血基因缺失的癌细胞中，对乙醛和其他物质的超敏反应。
Am J Pathol. 2014 Jan;184(1):260-70. doi: 10.1016/j.ajpath.2013.09.023. Epub 2013 Nov 6.
3
Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis.
乙醛在体外刺激人细胞中的FANCD2单泛素化、H2AX磷酸化和BRCA1磷酸化：对酒精相关致癌作用的影响。
Mutat Res. 2009 May 12;664(1-2):77-83. doi: 10.1016/j.mrfmmm.2009.03.011. Epub 2009 Apr 5.
4
Polyamines stimulate the formation of mutagenic 1,N2-propanodeoxyguanosine adducts from acetaldehyde.多胺可促进乙醛形成具有诱变作用的1,N2-丙基脱氧鸟苷加合物。
Nucleic Acids Res. 2005 Jun 21;33(11):3513-20. doi: 10.1093/nar/gki661. Print 2005.
5
Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases.乙醛诱导产生的特定串联GG到TT碱基替换是由于相邻鸟嘌呤碱基之间的链内交联。
Nucleic Acids Res. 1998 Apr 1;26(7):1769-74. doi: 10.1093/nar/26.7.1769.
6
Increased frequency of sister-chromatid exchanges in alcoholics.酗酒者姐妹染色单体交换频率增加。
Mutat Res. 1981 Apr;85(2):71-6. doi: 10.1016/0165-1161(81)90022-4.
7
Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.致突变性试验中的姐妹染色单体交换（SCE）和染色体结构畸变
Hum Genet. 1981;58(3):235-54. doi: 10.1007/BF00294917.