Gerber G B, Maes J
Radiat Environ Biophys. 1981;19(3):173-9. doi: 10.1007/BF01324184.
The radiosensitivity of hemopoietic stem cells isolated from infant mice (6 or 9 days of life), of infant preirradiated mice (exposed to 126 rad on day 6 and assayed at day 9 of life) and of adult C57/Bl mice was assayed on the basis of their capacity to form spleen colonies and to incorporate iododeoxyuridine after transplantation into heavily irradiated hosts. Stem cells of infant non-irradiated mice have a DO of 115 rad compared to 72 rad for adult mice whereas the DO of preirradiated infant mice has diminished to 80 rad. No significant difference was seen between spleen and bone marrow cells or between total cells and cells not sensitive to 3H-thymidine. It is postulated that this sensitization of stem cells caused by a preirradiation is responsible for the greater mortality of infant mice after fractionated exposure compared to a single one.
根据从新生小鼠（出生6或9天）、预先受过照射的新生小鼠（出生第6天接受126拉德照射，出生第9天进行测定）以及成年C57/Bl小鼠中分离出的造血干细胞在移植到受重度照射的宿主体内后形成脾集落和掺入碘脱氧尿苷的能力，对其放射敏感性进行了测定。未受照射的新生小鼠的干细胞的D0为115拉德，成年小鼠为72拉德，而预先受过照射的新生小鼠的D0已降至80拉德。在脾细胞和骨髓细胞之间，或在总细胞和对3H-胸腺嘧啶不敏感的细胞之间，未观察到显著差异。据推测，预先照射引起的干细胞这种致敏作用是导致新生小鼠分次照射后比单次照射后死亡率更高的原因。
