Singh P N, Sharma P, Gupta P K, Pandey K
Br J Anaesth. 1981 Aug;53(8):831-6. doi: 10.1093/bja/53.8.831.
Morphine 10 mg or diazepam 10 mg or a mixture of morphine 5 mg and diazepam 5 mg were given i.m. to three groups of 35 patients for relief of pain in the period immediately after operation. The patients had undergone upper abdominal operation for which a uniform regime of premedication and anaesthesia had been used. Pain was assessed by an observer before and after treatment and by the subjects, using a five-point scoring scheme. The pain scores before treatment and at 30-, 60-, 90- and 120-min intervals after treatment were compared by Ridit analysis. All three treatments produced significant relief, but the relief after diazepam alone was not as long-lasting as after the other two treatments. No clinically significant cardiovascular or respiratory complications occurred. Diazepam alone was associated with significantly more restlessness and morphine alone was associated with significantly more sickness. The combination of morphine and diazepam was considered to be the treatment of choice.
对三组各35例患者肌内注射10毫克吗啡、10毫克地西泮或5毫克吗啡与5毫克地西泮的混合物，以缓解术后即刻的疼痛。这些患者均接受了上腹部手术，且采用了统一的术前用药和麻醉方案。治疗前后由一名观察者以及受试者采用五点评分法对疼痛进行评估。通过Ridit分析比较治疗前以及治疗后30分钟、60分钟、90分钟和120分钟时的疼痛评分。所有三种治疗方法均产生了显著的疼痛缓解效果，但单独使用地西泮后的缓解效果不如其他两种治疗方法持久。未出现具有临床意义的心血管或呼吸系统并发症。单独使用地西泮与明显更多的躁动相关，单独使用吗啡与明显更多的恶心相关。吗啡和地西泮的联合使用被认为是首选治疗方法。
