氯唑坚牢红2BL的补体抑制和抗炎特性
Complement-inhibiting and anti-inflammatory properties of chlorazole fast pink 2BL.
作者信息
Doherty N S
出版信息
Clin Exp Immunol. 1981 Feb;43(2):260-9.
Abstract
Chlorazole fast pink 2BL inhibited the classical complement pathway in rat serum both in vivo and in vitro. The in vitro potency of chlorazole fast pink against the alternative pathway could not be assessed accurately but it was clearly less than that against the classical pathway. The compound appears to bind strongly to albumin with a resulting decrease in potency in undiluted as compared to diluted serum. Anti-inflammatory activity was observed in models of inflammation known to be highly complement-dependent (direct passive Arthus, zymosan oedema) but not in models in which complement is not involved (dextran oedema) or plays a minor role (carrageenan oedema).
摘要
氯唑坚牢红2BL在体内和体外均能抑制大鼠血清中的经典补体途径。氯唑坚牢红对替代途径的体外效力无法准确评估，但明显低于其对经典途径的效力。该化合物似乎与白蛋白紧密结合，导致与稀释血清相比，在未稀释血清中的效力降低。在已知高度依赖补体的炎症模型（直接被动Arthus反应、酵母聚糖水肿）中观察到抗炎活性，但在补体不参与（右旋糖酐水肿）或起次要作用（角叉菜胶水肿）的模型中未观察到。
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