Larsen N A, Pakkenberg H, Damsgaard E, Heydorn K, Wold S
J Neurol Sci. 1981 Sep;51(3):437-46. doi: 10.1016/0022-510x(81)90120-9.
The concentrations of arsenic, manganese and selenium/g wet tissue weight were determined in samples from 24 areas of the human brain from 3 patients with chronic renal insufficiency, 2 with Parkinson's disease and 1 with amyotrophic lateral sclerosis. The concentrations of the 3 elements were determined for each sample by neutron activation analysis with radiochemical separation. Overall arsenic concentrations were about 2.5 times higher in patients with chronic renal failure than in controls, and lower than normal in the patients with Parkinson's disease and amyotrophic lateral sclerosis. There were no obvious differences in the overall concentrations of manganese and selenium from one group to another. Even multivariate data analysis by the SIMCA method failed to reveal any significant difference in the distribution pattern of manganese and selenium in Parkinson's disease compared to normal controls.
对3例慢性肾功能不全患者、2例帕金森病患者和1例肌萎缩侧索硬化症患者大脑24个区域的样本，测定了砷、锰和硒的浓度/湿组织重量。通过放射化学分离的中子活化分析法测定每个样本中这3种元素的浓度。慢性肾衰竭患者的砷总浓度约为对照组的2.5倍，而帕金森病和肌萎缩侧索硬化症患者的砷总浓度低于正常水平。各组之间锰和硒的总浓度没有明显差异。即使采用SIMCA方法进行多变量数据分析，也未能揭示帕金森病患者与正常对照组相比，锰和硒的分布模式有任何显著差异。
