Grubb R L, Raichle M E, Higgins C S, Eichling J O
Ann Neurol. 1978 Oct;4(4):322-8. doi: 10.1002/ana.410040407.
The technique of positron emission tomography was used to measure cerebral blood volume (CBV) in 10 normal right-handed human volunteers following inhalation of trace quantities of cyclotron-produced, 11C-labeled carbon monoxide. In scans obtained 4 cm above the orbitomeatal line, CBV was 4.3 ml per 100 gm of tissue, whereas in scans obtained 8 cm above the orbitomeatal line, CBV was significantly less (3.3 ml per 100 gm; p less than 0.001). This difference reflects the greater proportion of gray matter in the lower scan. Furthermore, the CBV was significantly larger (p less than 0.001) in the left cerebral hemisphere in the tomographic scans obtained 4 cm above the orbitomeatal line. These scans include the region of the superior surface of the temporal lobe (planum temporale), which is thought to be larger in individuals with left cerebral dominance for speech. This observation is the first in vivo demonstration of a structural correlate of a known functional difference in the cerebral hemispheres of man.
采用正电子发射断层扫描技术，对10名正常右利手人类志愿者吸入微量回旋加速器产生的11C标记一氧化碳后的脑血容量（CBV）进行测量。在眶耳线以上4厘米处获得的扫描图像中，CBV为每100克组织4.3毫升，而在眶耳线以上8厘米处获得的扫描图像中，CBV显著降低（每100克3.3毫升；p<0.001）。这种差异反映了较低层面扫描图像中灰质比例更高。此外，在眶耳线以上4厘米处获得的断层扫描图像中，左侧大脑半球的CBV显著更大（p<0.001）。这些扫描图像包括颞叶上表面区域（颞平面），一般认为在言语功能左脑优势的个体中该区域更大。这一观察结果首次在活体中证实了人类大脑半球已知功能差异的结构相关性。
