de Sa D J
Arch Dis Child. 1978 Oct;53(10):769-76. doi: 10.1136/adc.53.10.769.
The adrenal glands of 41 fresh stillbirths were studied and a 'stress response' pattern could be seen in 28. In these glands the stress response was characterised by compact cell change, lipid depletion, excess pyroninophilia, and dilatation of the very prominent granular endoplasmic reticulum. Scattered areas of cytolysis of cells, especially of the definitive cortex, gave rise to the commonly seen cystic (pseudofollicular) change and it was obvious that cells undergoing lysis were severely 'stressed'. In 2 infants there was a 'clear cell reversal' pattern. Histological and ultrastructural changes of the stress response were not identified in 11. Infants of low birthweight score were somewhat more commonly represented in the group that did not show a stress response. Cytolytic changes accompanying a stress response were commoner in immature infants. It is argued that cystic (pseudofollicular) change in the adrenal cortex of the newborn signifies a previous stress reaction.
对41例新鲜死产儿的肾上腺进行了研究，其中28例可见“应激反应”模式。在这些肾上腺中，应激反应的特征为细胞致密化改变、脂质耗竭、嗜派洛宁性增强以及非常显著的粗面内质网扩张。细胞溶解的散在区域，尤其是在永久性皮质，导致了常见的囊性（假滤泡性）改变，并且明显正在溶解的细胞处于严重“应激”状态。2例婴儿呈现“透明细胞逆转”模式。11例未发现应激反应的组织学和超微结构改变。低出生体重评分的婴儿在未表现出应激反应的组中所占比例略高。伴随应激反应的细胞溶解变化在未成熟婴儿中更为常见。有人认为，新生儿肾上腺皮质的囊性（假滤泡性）改变表明先前存在应激反应。
