血清剥夺对小鼠3T3细胞生长的影响。与通过[⁸⁶Rb]铷离子摄取测量的钾离子转运变化无关。
Effect of imposed serum deprivation on growth of the mouse 3T3 cell. Dissociation from changes in potassium ion transport as measured from [86Rb)rubidium ion uptake.
作者信息
Tupper J T, Zografos L
出版信息
Biochem J. 1978 Sep 15;174(3):1063-5. doi: 10.1042/bj1741063.
Abstract
Decreased serum concentrations that substantially alter the growth of normal 3T3 cells alter neither the active and non-active components of unidirectional (86)Rb(+) influx nor the intracellular K(+) content when compared with cells in exponential growth. Thus the changes in K(+) transport (measured with (86)Rb(+) as an analogue for K(+) movements) that occur on density-dependent growth inhibition of the mouse 3T3 cell are not mimicked by serum deprivation of the cells before density inhibition.
摘要
与处于指数生长期的细胞相比，血清浓度降低虽能显著改变正常3T3细胞的生长，但既不改变单向（86）Rb（+）内流的活性和非活性成分，也不改变细胞内K（+）含量。因此，在小鼠3T3细胞密度依赖性生长抑制时发生的K（+）转运变化（用（86）Rb（+）作为K（+）移动的类似物进行测量），在密度抑制前血清剥夺细胞的情况下并未出现。
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