Easty D M, Easty G C, Carter R L, Monaghan P, Pittam M R, James T
Br J Cancer. 1981 Sep;44(3):363-70. doi: 10.1038/bjc.1981.193.
Five tumour cell lines have been derived from a primary squamous carcinoma of the tongue, from 2 subsequent local recurrences, and from 2 lymph-node metastases--all from the same patient. While the cell lines shared many morphological and biochemical characteristics, those derived from recurrences and metastases appeared to be less differentiated, were less well organized in culture, and displayed fewer desmosomes and tonofilaments than cells in the primary tumour line. A recurrent line showing greatest morphological divergence from the primary tumour line also demonstrated the greatest differences at the ultrastructural level, in increased production of plasminogen activator and in the composition of cell-surface glycoproteins.
五个肿瘤细胞系源自一名患者舌部的原发性鳞状细胞癌、随后的2次局部复发肿瘤以及2个淋巴结转移灶。虽然这些细胞系具有许多形态学和生化特征，但源自复发肿瘤和转移灶的细胞系似乎分化程度较低，在培养中组织性较差，并且与原发性肿瘤细胞系中的细胞相比，桥粒和张力丝较少。一个与原发性肿瘤细胞系形态差异最大的复发细胞系在超微结构水平、纤溶酶原激活物产生增加以及细胞表面糖蛋白组成方面也表现出最大差异。
