Wagstaff J, Gibson C, Thatcher N, Ford W L, Sharma H, Crowther D
Clin Exp Immunol. 1981 Mar;43(3):443-9.
Clinical studies using indium-111 oxine labelling of human peripheral blood lymphocytes are presented. Data from animal models of lymphocyte migration are compared with results found in healthy subjects and patients with malignant neoplasms. The physiological significance of bone marrow and liver localization on gamma camera imaging is discussed and the importance of considering the surface marker characteristics of the lymphocytes under study, when interpreting results, is emphasized. The possibility that the redistribution of lymphocytes within the body is a cause of the peripheral blood lymphopenia in patients with Hodgkin's disease and other malignancies is suggested, and the usefulness of indium-111 oxine labelling in clarifying this problem is proposed.
本文介绍了使用铟 - 111 奥克辛标记人外周血淋巴细胞的临床研究。将淋巴细胞迁移动物模型的数据与健康受试者和恶性肿瘤患者的结果进行了比较。讨论了γ相机成像中骨髓和肝脏定位的生理意义，并强调在解释结果时考虑所研究淋巴细胞表面标志物特征的重要性。提出了体内淋巴细胞重新分布可能是霍奇金病和其他恶性肿瘤患者外周血淋巴细胞减少原因的可能性，并提出了铟 - 111 奥克辛标记在阐明这一问题方面的有用性。
