Hendry W F, Stedronska J, Parslow J, Hughes L
Fertil Steril. 1981 Sep;36(3):351-5. doi: 10.1016/s0015-0282(16)45737-7.
Forty-five males who had been infertile for 2 to 10 (average 5.3) years, with significantly positive antisperm antibody tests (serum spermagglutination titers more than 32) and demonstrably improved sperm penetration of cervical mucus, were treated with repeated 7-day courses of methylprednisolone (MP) 32 mg three times a day from days 21 to 28 (in a few cases days 1 to 7) of their wives' menstrual cycles. Antisperm antibody tests were repeated after treatment and related to the occurrence of pregnancy in the wife. Fourteen wives (31%) became pregnant in a cycle following treatment of the husband. The production of pregnancy was always associated with a marked drop in sperm immobilizing titer and usually with disappearance of antibodies from seminal plasma; both of these effects were sometimes observed without a significant change in serum spermagglutination titers. Three patients (6%) had transient severe side effects, and 14 (26%) have had mild side effects, out of 54 patients treated so far.
45名男性不育患者，不育时间为2至10年（平均5.3年），抗精子抗体检测呈显著阳性（血清精子凝集效价超过32），且精子穿透宫颈黏液能力明显改善，在其妻子月经周期的第21至28天（少数情况为第1至7天）接受了为期7天的甲基强的松龙（MP）重复疗程治疗，剂量为每日3次，每次32毫克。治疗后重复进行抗精子抗体检测，并与妻子怀孕情况相关联。14名妻子（31%）在丈夫治疗后的一个周期内怀孕。怀孕的产生总是与精子制动效价显著下降相关，且通常与精浆中抗体消失有关；有时在血清精子凝集效价无显著变化的情况下也会观察到这两种效应。在目前治疗的54名患者中，3名患者（6%）出现短暂的严重副作用，14名患者（26%）出现轻微副作用。
