拟杆菌属诱导和抑制多形核中性粒细胞趋化作用
Polymorphonuclear neutrophil chemotaxis induced and inhibited by Bacteroides spp.
作者信息
Adamu S A, Sperry J F
出版信息
Infect Immun. 1981 Sep;33(3):806-10. doi: 10.1128/iai.33.3.806-810.1981.
Abstract
A possible virulence factor for Bacteroides subcutaneous abscesses has been found. The effect of Bacteroides culture filtrate and outer membrane on chemotaxis of rabbit peritoneal polymorphonuclear (PMN) neutrophils was assayed in Boyden chambers and via exocytosis of N-acetyl-beta-glucosaminidase. Both Bacteroides culture filtrate and outer membrane elicited some chemotaxis, as measured in the Boyden chamber; however, they had little effect upon exocytosis in cytochalasin B-treated PMN neutrophils. In the presence of serum complement, they completely abolished PMN neutrophil movement in the Boyden chamber assay, yet they gave a definite positive response for the exocytosis assay in the presence of serum complement or activated complement fragment.
摘要
已发现一种可能导致拟杆菌皮下脓肿的毒力因子。在博伊登小室中并通过N-乙酰-β-葡萄糖胺酶的胞吐作用，测定了拟杆菌培养滤液和外膜对兔腹膜多形核（PMN）中性粒细胞趋化性的影响。如在博伊登小室中所测，拟杆菌培养滤液和外膜均引发了一定程度的趋化性；然而，它们对细胞松弛素B处理的PMN中性粒细胞的胞吐作用影响很小。在血清补体存在的情况下，它们在博伊登小室试验中完全抑制了PMN中性粒细胞的移动，但在血清补体或活化补体片段存在的情况下，它们在胞吐作用试验中给出了明确的阳性反应。
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