正常人免疫球蛋白M、G和A参与人多形核白细胞对脆弱拟杆菌和嗜热栖热放线菌的调理吞噬作用及细胞内杀伤。
Participation of normal human immunoglobulins M, G, and A in opsonophagocytosis and intracellular killing of Bacteroides fragilis and Bacteroides thetaiotaomicron by human polymorphonuclear leukocytes.
作者信息
Bjornson A B, Bjornson H S, Kitko B P
出版信息
Infect Immun. 1980 May;28(2):633-7. doi: 10.1128/iai.28.2.633-637.1980.
Abstract
Restoration of the ability of hypogammaglobulinemic serum to support opsonophagocytosis and intracellular killing of Bacteroides fragilis and Bacteroides thetaiotaomicron by human polymorphonuclear leukocytes was achieved by supplementation with normal human immunoglobulin M, but not with normal human immunoglobulin G. Polymorphonuclear leukocyte bactericidal activity in the presence of immunoglobulin A-deficient human serum was equivalent to that observed in the presence of normal human serum.
摘要
通过补充正常人免疫球蛋白M而非正常人免疫球蛋白G，实现了低丙种球蛋白血症血清支持人多形核白细胞对脆弱拟杆菌和嗜内脏拟杆菌进行调理吞噬作用及细胞内杀伤的能力恢复。在缺乏免疫球蛋白A的人血清存在的情况下，多形核白细胞的杀菌活性与在正常人血清存在时观察到的活性相当。
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