Nakamoto T, Cheuk S L, Yoshino S, Falster A U, Simmons W B
Department of Physiology, Louisiana State University Medical Center, New Orleans 70119.
Arch Oral Biol. 1993 Oct;38(10):919-22. doi: 10.1016/0003-9969(93)90103-s.
Lactating dams with eight suckling pups were fed either a 20% protein diet as a control or experimentally a 20% protein diet supplemented with caffeine (2 mg/100g body weight) from the birth of the pups to day 22. At day 22, the pups from both groups were weaned and fed a cariogenic diet until day 50, when they were killed. Dental caries of the molars were scored from randomized mandibles. The enamel of the first molars in the caffeine group showed significantly higher caries scores than that of the controls. This appears to be the first unequivocal evidence that caffeine is a cariogenic agent when newborns are exposed to it during critical periods of tooth development. Therefore, the widespread human consumption of caffeine could be a threat to the healthy development of teeth.
给有八只吮乳幼崽的哺乳期母鼠喂食，一组作为对照喂以20%蛋白质饮食，另一组从幼崽出生到第22天实验性地喂以添加咖啡因（2毫克/100克体重）的20%蛋白质饮食。在第22天，两组幼崽断奶，并喂以致龋饮食直至第50天，然后将它们处死。从随机选取的下颌骨对臼齿的龋齿情况进行评分。咖啡因组第一磨牙的牙釉质龋齿评分显著高于对照组。这似乎是首个明确证据，表明在牙齿发育的关键时期让新生儿接触咖啡因，咖啡因是一种致龋剂。因此，人类广泛摄入咖啡因可能对牙齿的健康发育构成威胁。
