Goebell H, Rudolph H D, Breuer N, Hartmann W, Leder H D
Z Gastroenterol. 1981 Jul;19(7):345-55.
Out of 11 840 autopsies from 1940-1975 697 cases with cirrhosis of the liver were found. The percentages of gallstone disease in these cases was analyzed as compared to non - cirrhotic controls. 21,5% of cirrhotic patients had cholelithiasis versus 16,5% in the controls (p less than 0,001). In women 35,2% of cirrhotics versus 26,3% (p less than 0,01) and in men 16,2% versus 10,8% (p less than 0,001) were found with gallstones. Including cases with cholecystectomies the frequencies was 22,8% for cirrhosis and 19,9% for controls (men 16,9% versus 12,9%, women 37,7% versus 33,6%). These differences were not significant. The female to male ratio for the frequency of cholelithiasis was found to be 2,2 : 1 and was not altered as compared to be controls. In cirrhotic and control patients the frequency of cholelithiasis increased steadily with each decade of age, again more in women than in men. A tendency to higher frequencies for gallstones in cirrhotic patients was found from the 5th decade onwards, but this was not statistically significant.
在1940年至1975年的11840例尸检中，发现697例肝硬化病例。分析了这些病例中胆结石疾病的百分比，并与非肝硬化对照组进行比较。21.5%的肝硬化患者患有胆石症，而对照组为16.5%（p<0.001）。在女性中，35.2%的肝硬化患者患有胆石症，而对照组为26.3%（p<0.01）；在男性中，16.2%的肝硬化患者患有胆石症，而对照组为10.8%（p<0.001）。包括胆囊切除术病例在内，肝硬化患者的频率为22.8%，对照组为19.9%（男性为16.9%对12.9%，女性为37.7%对33.6%）。这些差异不显著。胆石症发生频率的女性与男性之比为2.2:1，与对照组相比没有变化。在肝硬化患者和对照组中，胆石症的发生频率随着每一个十年的年龄增长而稳步上升，女性上升幅度再次高于男性。从第五个十年开始，发现肝硬化患者胆石症的发生频率有升高趋势，但这在统计学上不显著。
