Maher J, Urano M, Rice L, Suit H D
Br J Radiol. 1981 Dec;54(648):1086-90. doi: 10.1259/0007-1285-54-648-1086.
Resistance to subsequent hyperthermia as a result of prior heating was investigated using a spontaneous murine tumour implanted into the feet of C3H/Sed mice. Tumours were treated by immersing the tumour-bearing foot into a constant-temperature hot water bath set at 45.5 degrees C and were given single and split doses of heat. Response was assessed using a tumour-growth time assay. Three aspects of thermally-induced resistance were particularly considered: the time course of development and decay; the importance of the magnitude of the priming dose and the influence of the size of the tumour at the time of treatment. Substantial resistance was induced in this tumour by short priming doses at 45.5 degrees C, rising rapidly 1-2 days after the first treatment and then starting to decay. There was no significant difference in the kinetics of thermal resistance induced in tumours treated at 4mm and those treated at 8 mm in size, although the large tumours were more sensitive to single doses of heat. Increasing the magnitude of the priming dose of heat resulted in an increase in the magnitude of resistance to the second dose. The results of this study are compared with results of similar studies in this and other laboratories using murine normal tissues and cells in culture. Possible clinical implications are considered.
利用植入C3H/Sed小鼠足部的自发性鼠肿瘤，研究了先前加热导致的对后续热疗的抗性。通过将荷瘤足浸入设定为45.5摄氏度的恒温水浴中来治疗肿瘤，并给予单次和分次热剂量。使用肿瘤生长时间测定法评估反应。特别考虑了热诱导抗性的三个方面：发展和衰退的时间进程；引发剂量大小的重要性以及治疗时肿瘤大小的影响。在45.5摄氏度下短时间引发剂量可在该肿瘤中诱导出显著抗性，在首次治疗后1-2天迅速上升，然后开始衰退。4毫米大小的肿瘤和8毫米大小的肿瘤在热抗性动力学方面没有显著差异，尽管大肿瘤对单次热剂量更敏感。增加热引发剂量的大小会导致对第二剂量抗性的大小增加。将本研究结果与本实验室和其他实验室使用小鼠正常组织和培养细胞的类似研究结果进行了比较。考虑了可能的临床意义。
