先天性无胸腺裸鼠的实验性Q热感染
Experimental Q fever infection in congenitally athymic nude mice.
作者信息
Kishimoto R A, Rozmiarek H, Larson E W
出版信息
Infect Immun. 1978 Oct;22(1):69-71. doi: 10.1128/iai.22.1.69-71.1978.
Abstract
Congenitally athymic nude (nu/nu) mice and their phenotypically normal (nu/+) euthymic littermates were exposed to Coxiella burnetii administered as small-particle aerosols. After challenge, both strains of mice became infected, as characterized by rickettsemia, viable rickettsiae in the spleen, and serological conversion. The major difference noted was that euthymic animals had cleared rickettsiae from peripheral circulation and the spleen within 14 days. In contrast, rickettsiae were detected and isolated from spleen and blood of athymic mice through 60 days.
摘要
将先天性无胸腺裸鼠（nu/nu）及其表型正常（nu/+）的有胸腺同窝小鼠暴露于以小颗粒气溶胶形式给予的伯纳特立克次体。攻毒后，两种品系的小鼠均被感染，表现为立克次体血症、脾脏中存在活的立克次体以及血清学转化。观察到的主要差异是有胸腺的动物在14天内从外周循环和脾脏中清除了立克次体。相比之下，在60天内均能从无胸腺小鼠的脾脏和血液中检测到并分离出立克次体。
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