感染斑点热群立克次体的豚鼠细胞免疫反应的抑制
Suppression of cellular immune responses in guinea pigs infected with spotted fever group rickettsiae.
作者信息
Oster C N, Kenyon R H, Pedersen C E
出版信息
Infect Immun. 1978 Nov;22(2):411-7. doi: 10.1128/iai.22.2.411-417.1978.
Abstract
Using a guinea pig model, we demonstrated that infections with pathogenic species of spotted fever group rickettsiae transiently and nonspecifically suppress established cellular immune responses as measured by in vitro lymphocyte transformation and in vivo delayed cutaneous hypersensitivity responses to unrelated, nonrickettsial antigens. The correlation of the duration of this immunosuppression with the virulence of the infecting rickettsial species suggests that this suppression is a pathological effect of the rickettsial infection. Although we did not specifically study the mechanism of this suppression, it is not associated with either lymphocytopenia or leukocytosis.
摘要
利用豚鼠模型，我们证明，通过体外淋巴细胞转化和体内对无关、非立克次体抗原的迟发型皮肤超敏反应来衡量，斑点热群立克次体的致病菌种感染会短暂且非特异性地抑制已建立的细胞免疫反应。这种免疫抑制的持续时间与感染立克次体菌种的毒力之间的相关性表明，这种抑制是立克次体感染的一种病理效应。虽然我们没有专门研究这种抑制的机制，但它与淋巴细胞减少或白细胞增多均无关。
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