兔热原试验和鲎试剂试验在预测疫苗对人体的致热原性方面的可靠性。
Reliability of the rabbit pyrogen test and of the limulus test in predicting the pyrogenicity of vaccines in man.
作者信息
Nyerges G, Jaszovszky I
出版信息
Acta Microbiol Acad Sci Hung. 1981;28(3):235-43.
Commercial vaccines including bacterial as well as live and inactivated viral vaccines were examined in the rabbit pyrogen test and in the limulus test. The laboratory results were compared with the reactivity in humans. A fairly good correlation was found between the temperature rise in rabbits and the frequency of febrile reaction in the vaccinees. Two rabies vaccines and a tick-borne encephalitis virus vaccine, each pyrogenic both in rabbit and in man. were negative in the limulus test. The pyrogenicity of these vaccines is attributed to the vaccine virus itself.
包括细菌性疫苗以及活病毒和灭活病毒疫苗在内的商用疫苗，均通过家兔热原试验和鲎试剂试验进行了检测。将实验室结果与人体反应性进行了比较。发现家兔体温升高与接种疫苗者发热反应频率之间存在相当良好的相关性。两种狂犬病疫苗和一种蜱传脑炎病毒疫苗，在家兔和人体中均具有致热性，但在鲎试剂试验中呈阴性。这些疫苗的致热性归因于疫苗病毒本身。
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