Burnstein A V, Galambos J T
Dig Dis Sci. 1981 Dec;26(12):1078-83. doi: 10.1007/BF01295971.
The [14C]aminopyrine breath test (APBT) score, an estimate of hepatic mixed-oxidase function, was evaluated in 21 consecutive patients wih active nonalcoholic chronic liver diseases. Ten had primary biliary cirrhosis (PBC) and 11 had chronic active hepatitis (CAH). The APBT score was normal or elevated in patients with PBC (P less than 0.001), and lower than normal in CAH patients (P less than 0.01); 10.5 +/- 1.6 and 3.5 +/- 1.86, respectively, vs control 7.65 +/- 1.15 (mean +/- SD). The 11 patients with CAH included two middle-aged women who displayed ambiguous severe intrahepatic cholestasis. There was no overlap between the APBT scores of the 10 PBC and 11 CAH patients. These initial data suggest that the APBT may be helpful in the differentiation of PBC and CAH, including misleading cholestatic forms of CAH.
对21例活动性非酒精性慢性肝病患者进行了[14C]氨基比林呼气试验（APBT）评分，该评分用于评估肝脏混合氧化酶功能。其中10例为原发性胆汁性肝硬化（PBC）患者，11例为慢性活动性肝炎（CAH）患者。PBC患者的APBT评分正常或升高（P<0.001），而CAH患者的评分低于正常水平（P<0.01）；分别为10.5±1.6和3.5±1.86，而对照组为7.65±1.15（均值±标准差）。11例CAH患者中有两名中年女性表现出严重的肝内胆汁淤积，情况不明。10例PBC患者和11例CAH患者的APBT评分没有重叠。这些初步数据表明，APBT可能有助于鉴别PBC和CAH，包括具有误导性的胆汁淤积型CAH。
