Oxford J S, Corcoran T, Schild G C
J Gen Virol. 1981 Oct;56(Pt 2):431-6. doi: 10.1099/0022-1317-56-2-431.
Intratypic electrophoretic mobility differences in high resolution SDS-polyacrylamide gels were detected between corresponding matrix (M) proteins, nucleoproteins (NP), haemagglutinin (HA) and the non-structural polypeptides NS1 and NS2 induced in Vero cells by human influenza A viruses of the antigenic subtypes H1N1 and H3N2. Such phenotypic differences were distinguishable in both H1N1 and H3N2 viruses isolated in single school and city outbreaks. Additional intratypic variation was detected in the biological property of virus plaquing in MDCK cells. Although the biochemical basis is not established, phenotypic variation could represent an additional factor influencing the epidemiology of influenza A viruses.
在高分辨率SDS-聚丙烯酰胺凝胶中，检测到抗原亚型H1N1和H3N2的甲型人流感病毒在Vero细胞中诱导产生的相应基质（M）蛋白、核蛋白（NP）、血凝素（HA）以及非结构多肽NS1和NS2之间存在型内电泳迁移率差异。在单个学校和城市爆发中分离出的H1N1和H3N2病毒中，这种表型差异都是可区分的。在MDCK细胞中病毒空斑形成的生物学特性方面检测到了额外的型内变异。尽管生化基础尚未明确，但表型变异可能是影响甲型流感病毒流行病学的另一个因素。
