苯妥英（Ph）治疗期间氢氯噻嗪（Hct）的处置情况。

Disposition of hydrochlorothiazide (Hct) during phenytoin (Ph) treatment.

作者信息

Keller E, Sulzer U, Brennes M, Schollmeyer P, Hoppe-Seyler G

出版信息

Klin Wochenschr. 1981 Nov 2;59(21):1223-4. doi: 10.1007/BF01721218.

Abstract

Plasma levels and urinary recovery of Hct were determined in seven healthy male volunteers. 75 mg Hct were administered as a tablet in a randomised fashion with or without phenytoin pretreatment (300 mg/d). Bioavailability of Hct showed considerable intra- and interindividual variation (32--87% and 42--77% respectively), but phenytoin did not influence the disposition parameters of the diuretic.

摘要

在7名健康男性志愿者中测定了血细胞比容（Hct）的血浆水平和尿回收率。以片剂形式随机给予75毫克Hct，同时给予或不给予苯妥英预处理（300毫克/天）。Hct的生物利用度显示出相当大的个体内和个体间差异（分别为32%-87%和42%-77%），但苯妥英并不影响利尿剂的处置参数。