Lückhoff A, Horster M
Pflugers Arch. 1981 Oct;391(4):301-5. doi: 10.1007/BF00581511.
The distal colon (rat) was perfused in vivo at low rates (1-2 ml/h). Dialyzed polyethyleneglycol 4,000 (PEG) was used to vary the luminal osmotic activity (pi eff). Perfusate sodium concentration of 3.7 mmol 1-1 +/- 0.9 (SD) resulted in an effluent Na+ of 3.3 mmol 1-1 +/- 1.4. Potassium concentrations of 15 or 25 mmol 1-1 remained unaltered. At this cationic steady-state, transmural net water flux (Jv) was linearly correlated (r = -0.96, n = 24) to the logarithm of pi eff. Jv was zero at 634 mosm 1-1. Lp (microliters h-1 cm-2 mosm-1 l) was 0.195 at pi eff 85 mosm 1-1 and 0.046 at 1,050 mosm 1-1. These data characterize the distal colon as an epithelium with high capacity for salt conservation.
以低流速（1 - 2毫升/小时）对大鼠远端结肠进行体内灌注。使用经透析的聚乙二醇4000（PEG）来改变肠腔渗透活性（πeff）。灌注液钠浓度为3.7毫摩尔/升±0.9（标准差）时，流出液钠浓度为3.3毫摩尔/升±1.4。15或25毫摩尔/升的钾浓度保持不变。在此阳离子稳态下，跨壁净水流（Jv）与πeff的对数呈线性相关（r = -0.96，n = 24）。在634毫渗量/升时Jv为零。在πeff为85毫渗量/升时Lp（微升·小时-1·厘米-2·毫渗量-1·升）为0.195，在1050毫渗量/升时为0.046。这些数据表明远端结肠是一种具有高保盐能力的上皮组织。
