Prellner K
Scand J Infect Dis. 1981;13(4):263-8. doi: 10.3109/inf.1981.13.issue-4.04.
Complement component levels (Clq, Cls, C4, C3, factor B and properdin) and C1 subcomponent complexes (C1r-C1s, C1-r-C1-, C1-r-C1-s-C1 inactivator, 1A) were studied in 16 adults with pneumococcal infections varying severity. Patients with fulminant disease and signs of septic shock showed pronounced hypocomplementemia. In patients with pneumococcal pneumonia or meningitis elevated levels of C1-r-C1-s-C1- IA complexes indicated activation of C1, despite normal levels of C1q, C1s, C4 and C3. Moderately decreased properdin values suggested involvement of the alternative pathway. In adults with pneumococcal otitis no changes in the complement profile was found. In contrast, pronounced aberrations of the C1 subcomponents were earlier demonstrated in children with otitis.
对16例病情严重程度各异的肺炎球菌感染成年患者的补体成分水平（C1q、C1s、C4、C3、B因子和备解素）及C1亚成分复合物（C1r - C1s、C1 - r - C1 - 、C1 - r - C1 - s - C1灭活剂、1A）进行了研究。暴发性疾病且有感染性休克体征的患者出现明显的补体低下。在肺炎球菌肺炎或脑膜炎患者中，尽管C1q、C1s、C4和C3水平正常，但C1 - r - C1 - s - C1 - IA复合物水平升高表明C1被激活。备解素值中度降低提示替代途径参与其中。在患有肺炎球菌性中耳炎的成年患者中，未发现补体谱有变化。相比之下，在患有中耳炎的儿童中，更早出现了C1亚成分的明显异常。
