Putz-Anderson V, Setzer J V, Croxton J S, Phipps F C
Scand J Work Environ Health. 1981 Mar;7(1):8-13. doi: 10.5271/sjweh.2563.
Human behavioral effects resulting from the ingestion of an average dose of diazepam and from 3 h of inhaling either 100 ppm or 200 ppm of methyl chloride (MeCl) were studied in the laboratory. Each of 56 volunteers was randomly assigned to one of six groups comprising the combinations of diazepam and placebo and one of the two levels of MeCl plus control. Each individual was tested in an environmental room on three tasks involving components of eye-hand coordination, mental alertness, and time discrimination. Both pretreatment and treatment data were obtained. Diazepam produced a significant 10% impairment in task performance, whereas the effect of 200 ppm of MeCl was marginally significant (average performance impairment of 4.5%). When the two agents were combined, total impairment was equal to the sum of the individually induced losses. Large interindividual differences in breath and blood levels were found for MeCl.
在实验室中研究了摄入平均剂量的地西泮以及吸入3小时100 ppm或200 ppm氯甲烷（MeCl）对人类行为的影响。56名志愿者中的每一位都被随机分配到六个组中的一组，这六个组包括地西泮和安慰剂的组合，以及两种水平的MeCl加对照组中的一种。每个个体在环境室中接受三项任务的测试，这些任务涉及眼手协调、精神警觉性和时间辨别等方面。同时获取了预处理和处理后的数据。地西泮使任务表现显著降低了10%，而200 ppm的MeCl的影响则略显显著（平均表现降低4.5%）。当两种药剂联合使用时，总的降低程度等于各自单独引起的降低程度之和。发现MeCl在呼吸和血液水平上存在较大的个体差异。
