Rampling M W
Acta Biol Med Ger. 1981;40(4-5):373-8.
A study has been made of the binding of fibrinogen to erythrocyte membranes. The amount of fibrinogen bound is found to be proportional to the concentration in the suspending phase (up to 10 g/l) and to be unaffected by other plasma proteins or calcium ions (up to normal concentrations). The binding is also unaffected by temperature (between 4 and 37 degrees C). However it is sensitive to both pH and ionic strength variation. A similar study of the major fibrinogen degradation products (FDP) produced by plasmin shows that these all bind to red cell membranes but by different amounts. A model based on these data is suggested for the positions of the binding regions on the fibrinogen and FDP molecules and is used to explain their influence on rouleaux formation and on the flexibility of the erythrocyte.
已经对纤维蛋白原与红细胞膜的结合进行了一项研究。发现结合的纤维蛋白原量与悬浮相中（高达10 g/l）的浓度成正比，并且不受其他血浆蛋白或钙离子（直至正常浓度）的影响。结合也不受温度（4至37摄氏度之间）的影响。然而，它对pH值和离子强度变化敏感。对纤溶酶产生的主要纤维蛋白原降解产物（FDP）进行的类似研究表明，这些产物都能与红细胞膜结合，但结合量不同。基于这些数据，提出了一个关于纤维蛋白原和FDP分子上结合区域位置的模型，并用于解释它们对红细胞缗钱状形成和红细胞柔韧性的影响。
