Mangla P K, Menon M P
Clin Allergy. 1981 Sep;11(5):433-9. doi: 10.1111/j.1365-2222.1981.tb01616.x.
The effect of nasal as well as oral breathing during level-ground running for 6 min on the post exercise bronchial response was studied in fifteen people (five asthmatics with exercise liability, five asthmatics with no such liability and five normals). Each patient did the exercise twice; once with the nose clipped and once with the mouth closed. FEV1 was measured before exercise, immediately after exercise and at 5, 10, 15, 20 and 30 min thereafter. A fall in FEV1 of 20% or more from the basal level was taken as evidence of bronchoconstriction. When the patients were required to breath only through the nose during the exercise, the post-exercise bronchoconstrictive response was markedly reduced as compared with the response obtained by oral breathing during exercise, indicating a beneficial effect of nasal breathing. Nasal breathing was beneficial as compared with oral breathing in normals as well. In the five asthmatics with no exercise liability no appreciable difference was observed. This study suggests that the oropharynx and nasopharynx play important roles in the causation of exercise-induced asthma.
在15名受试者（5名运动诱发哮喘患者、5名无运动诱发哮喘的哮喘患者和5名正常人）中，研究了6分钟平地上跑步时鼻呼吸和口呼吸对运动后支气管反应的影响。每位受试者进行两次运动；一次夹鼻，一次闭嘴。在运动前、运动后即刻以及此后5、10、15、20和30分钟测量第一秒用力呼气量（FEV1）。FEV1较基础水平下降20%或更多被视为支气管收缩的证据。当受试者在运动期间仅通过鼻子呼吸时，与运动期间口呼吸所获得的反应相比，运动后支气管收缩反应明显降低，表明鼻呼吸具有有益作用。与口呼吸相比，鼻呼吸对正常人也有益。在5名无运动诱发哮喘的哮喘患者中未观察到明显差异。这项研究表明，口咽和鼻咽在运动诱发哮喘的发病机制中起重要作用。
