人肺组织中分离出的肥大细胞上IgE受体的数量和亲和力。
The number and affinity of IgE receptors on dispersed human lung mast cells.
作者信息
Coleman J W, Godfrey R C
出版信息
Immunology. 1981 Dec;44(4):859-63.
Abstract
Mast cells obtained by fragmentation of human lung tissue retained the capacity to bind IgE and to respond to immunological challenge. Direct binding studies with radiolabelled IgE enabled quantification of binding parameters of the reaction between IgE and its receptor on human mast cells. The average equilibrium constant was estimated as 1.0 x 10(8) M -1 and the average number of IgE receptors per mast cell as 1.3 x 10(5).
摘要
通过人肺组织破碎获得的肥大细胞保留了结合IgE和对免疫刺激作出反应的能力。用放射性标记的IgE进行的直接结合研究能够对IgE与其在人肥大细胞上的受体之间反应的结合参数进行定量。平均平衡常数估计为1.0×10⁸ M⁻¹，每个肥大细胞上IgE受体的平均数为1.3×10⁵。
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