维兰霉素，一种由链霉菌菌株产生的新型抗病毒抗生素。

Virantmycin, a new antiviral antibiotic produced by a strain of Streptomyces.

作者信息

Nakagawa A, Iwai Y, Hashimoto H, Miyazaki N, Oiwa R, Takahashi Y, Hirano A, Shibukawa N, Kojima Y, Omura S

出版信息

J Antibiot (Tokyo). 1981 Nov;34(11):1408-15. doi: 10.7164/antibiotics.34.1408.

DOI:10.7164/antibiotics.34.1408

PMID:7319904

Abstract

Virantmycin, a novel chlorine-containing antiviral antibiotic, has been isolated from Streptomyces nitrosporeus No. AM-2722. The active substance in culture broth is isolated as colorless needles by solvent extraction followed by high performance liquid chromatography on silicic acid. The molecular formula is C19H26NO3Cl (molecular weight 351) from the elemental analysis and mass spectrum. The antibiotic possesses antifungal activity and potent inhibitory activity against various RNA and DNA viruses.

摘要

维兰霉素是一种新型含氯抗病毒抗生素，从链霉菌属的嗜硝化孢子菌AM - 2722号菌株中分离得到。通过溶剂萃取，然后在硅酸上进行高效液相色谱法，将培养液中的活性物质分离为无色针状晶体。根据元素分析和质谱，其分子式为C₁₉H₂₆NO₃Cl（分子量351）。该抗生素具有抗真菌活性以及对多种RNA和DNA病毒的强效抑制活性。