潜在的抗肿瘤药物。十七。来自可可球花假茄的酸浆苦素B和25,26-表二氢酸浆苦素C。
Potential antitumor agents. XVII. physalin B and 25,26-epidihydrophysalin C from Witheringia coccoloboides.
作者信息
Antoun M D, Abramson D, Tyson R L, Chang C J, McLaughlin J L, Peck G, Cassady J M
出版信息
J Nat Prod. 1981 Sep-Oct;44(5):579-85. doi: 10.1021/np50017a013.
An investigation of Witheringia coccoloboides (Dammer) A. T. Hunziker [Capsicum fuscoviolaceum (Cufodontis) Mort. And Standl.] roots has resulted in the isolation of two cytotoxic compounds: physalin B (1) and a novel physalin, which was characterized by spectral analysis as 25,26-epidihydrophysalin C (2). Both compounds have demonstrated cytotoxic activity in 9KB and 9PS tumor cells (in vitro). Physalin B (1) has demonstrated moderate activity against the 3PS mouse leukemia (in vivo).
对 Witheringia coccoloboides（达默）A. T. 洪齐克 [Capsicum fuscoviolaceum（库福多蒂斯）莫尔特和斯坦德尔] 根的研究导致分离出两种细胞毒性化合物：酸浆苦素 B（1）和一种新型酸浆苦素，通过光谱分析鉴定为 25,26-表二氢酸浆苦素 C（2）。这两种化合物在体外对 9KB 和 9PS 肿瘤细胞均表现出细胞毒性活性。酸浆苦素 B（1）在体内对 3PS 小鼠白血病表现出中等活性。
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