Danielsson K, Evers H, Nordenram A
Anesth Prog. 1985 Mar-Apr;32(2):65-8.
The effect of bupivacaine 7.5 mg/ml with epinephrine 5μg/ml, etidocaine 15 mg/ml with epinephrine 5 μg/ml, and lidocaine 20 mg/ml with epinephrine 12.5 μg/ml was studied when used for oral infiltration anesthesia. Twenty healthy volunteers took part in the experimental and double-blind study. One ml of the respective anesthetic solution was deposited supraperiosteally in the apical area of the maxillary right lateral incisor. Onset time, frequency of analgesia, gingival spread, and duration of tooth analgesia were studied and duration of soft-tissue numbness registered. The present investigation showed that lidocaine had a shorter onset time compared with bupivacaine. No difference with regard to frequency was found. Bupivacaine and etidocaine had a longer period of soft-tissue numbness, but a significantly shorter duration of tooth analgesia than lidocaine.
研究了含肾上腺素5μg/ml的7.5mg/ml布比卡因、含肾上腺素5μg/ml的15mg/ml依替卡因以及含肾上腺素12.5μg/ml的20mg/ml利多卡因用于口腔浸润麻醉时的效果。20名健康志愿者参与了这项实验性双盲研究。将1ml相应的麻醉溶液骨膜上注射于右上颌侧切牙根尖区。研究了起效时间、镇痛频率、牙龈扩散范围以及牙齿镇痛持续时间，并记录软组织麻木持续时间。本研究表明，与布比卡因相比，利多卡因起效时间更短。在频率方面未发现差异。布比卡因和依替卡因的软组织麻木持续时间更长，但牙齿镇痛持续时间明显短于利多卡因。
