在人和动物尿液中对木脂素反式-2,3-双(3-羟基苄基)-γ-丁内酯和2,3-双(3-羟基苄基)丁烷-1,4-二醇的确证鉴定。
The definitive identification of the lignans trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol in human and animal urine.
作者信息
Setchell K D, Lawson A M, Conway E, Taylor N F, Kirk D N, Cooley G, Farrant R D, Wynn S, Axelson M
出版信息
Biochem J. 1981 Aug 1;197(2):447-58. doi: 10.1042/bj1970447.
Abstract
The definitive identification of the first lignans to be found in humans and animals is described. Gas chromatography--mass spectrometry, n.m.r. spectroscopy, i.r. spectroscopy and chemical techniques were employed to establish the structures of two lignans as trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol. Both compounds are essetially racemic. Evidence was also found for several methoxy analogues of these lignans in the vervet monkey.
摘要
本文描述了在人类和动物中首次发现的木脂素的确切鉴定过程。采用气相色谱 - 质谱联用、核磁共振光谱、红外光谱和化学技术确定了两种木脂素的结构，分别为反式 - 2,3 - 双（3 - 羟基苄基）-γ-丁内酯和2,3 - 双（3 - 羟基苄基）丁烷 - 1,4 - 二醇。这两种化合物基本上都是外消旋体。在绿猴中还发现了这些木脂素的几种甲氧基类似物的证据。
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