硝基咪唑对植物脂肪酸合成的抑制作用。
Inhibition of plant fatty acid synthesis by nitroimidazoles.
作者信息
Jones A V, Harwood J L, Stratford M R, Stumpf P K
出版信息
Biochem J. 1981 Jul 15;198(1):193-8. doi: 10.1042/bj1980193.
Abstract
- The effect of the addition of a number of nitroimidazoles was tested on fatty acid synthesis by germinating pea seeds, isolated lettuce chloroplasts and a soluble fraction from pea seeds. 2. All the compounds tested had a marked inhibition on stearate desaturation by lettuce chloroplasts and on the synthesis of very-long-chain fatty acids by pea seeds. 3. In contrast, the effect of the drugs on total fatty acid synthesis from [14C]acetate in chloroplasts was related to the compound's electron reduction potentials. 4. Of the compounds used, only metronidazole had a marked inhibition on palmitate elongation in the systems tested. 5. The mechanism of inhibition of plant fatty acid synthesis by nitroimidazoles is discussed and the possible relevance of these findings to their neurotoxicity is suggested.
摘要
- 测试了多种硝基咪唑对豌豆种子萌发、离体生菜叶绿体以及豌豆种子可溶性部分脂肪酸合成的影响。2. 所有测试的化合物对生菜叶绿体中硬脂酸去饱和以及豌豆种子中极长链脂肪酸的合成均有显著抑制作用。3. 相比之下，这些药物对叶绿体中由[14C]乙酸合成总脂肪酸的影响与化合物的电子还原电位有关。4. 在所用的化合物中，仅甲硝唑对测试体系中棕榈酸的延长有显著抑制作用。5. 讨论了硝基咪唑抑制植物脂肪酸合成的机制，并提出了这些发现与其神经毒性可能的相关性。
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