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肝损伤对饥饿大鼠酮体生成及氮平衡的影响。

Effects of liver damage on ketone-body production and nitrogen balance in starved rats.

作者信息

Flatt J P, Quail J M

出版信息

Biochem J. 1981 Jul 15;198(1):227-30. doi: 10.1042/bj1980227.

DOI:10.1042/bj1980227
PMID:7325997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163232/
Abstract

The metabolic effects of intraperitoneal administration of carbon tetrachloride (1ml/kg) were studied in starved rats. The most notable change in circulating substrates was an 80% fall in ketone-body concentrations, which was associated with the doubling of urinary nitrogen losses. The results demonstrate the importance of starvation ketosis in permitting fat mobilization to decrease effectively protein losses during starvation.

摘要

在饥饿的大鼠中研究了腹腔注射四氯化碳(1毫升/千克)的代谢效应。循环底物中最显著的变化是酮体浓度下降80%,这与尿氮损失增加一倍有关。结果表明,饥饿性酮症在饥饿期间允许脂肪动员以有效减少蛋白质损失方面具有重要作用。

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本文引用的文献

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Microdetermination of long-chain fatty acids in plasma and tissues.血浆和组织中长链脂肪酸的微量测定
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Brain metabolism during fasting.禁食期间的脑代谢。
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Critical variables in the radioimmunoassay of serum insulin using the double antibody technic.采用双抗体技术进行血清胰岛素放射免疫测定中的关键变量。
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Prevention by cystamine of liver necrosis and early biochemical alterations induced by carbon tetrachloride.胱胺对四氯化碳诱导的肝坏死及早期生化改变的预防作用。
Biochem Pharmacol. 1972 Jan;21(1):49-57. doi: 10.1016/0006-2952(72)90249-3.
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Rate control of the tricarboxylic acid cycle.三羧酸循环的速率调控
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Starvation in man.人类的饥饿
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9
Metabolic studies in experimental liver disease resulting from D(+)-galactosamine administration.由给予D(+)-半乳糖胺所致实验性肝病的代谢研究。
Biochem J. 1972 Nov;130(1):37-44. doi: 10.1042/bj1300037.
10
Effect of nicotinamide on carbohydrate metabolism in the rat liver during starvation.饥饿期间烟酰胺对大鼠肝脏碳水化合物代谢的影响。
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