Grohmann P H, Porzsolt F, Quirt I, Miller R G, Phillips R A
Clin Exp Immunol. 1981 Jun;44(3):611-4.
Incubation of mononuclear cells with a melanoma tumour cell. M4, induces a rapid increase in NK cell activity in both normal and tumour patient cells. A marked individual variation among the patient population can be attributed to the prior ingestion of aspirin. Single therapeutic doses of aspirin (two tablets, 660 mg) taken 12 hr prior to donation of the blood sample cause an 80-100% reduction in the NK cell activity induced by M4. Since many patients coming to cancer clinics take aspirin regularly, it is essential that they be questioned about their recent usage of this drug if their cells are to be used in assays for NK activity.
将单核细胞与黑色素瘤肿瘤细胞M4一起培养，会使正常细胞和肿瘤患者细胞中的自然杀伤（NK）细胞活性迅速增加。患者群体中存在显著的个体差异，这可能归因于之前服用过阿司匹林。在采集血样前12小时服用单剂量治疗性阿司匹林（两片，660毫克），会使M4诱导的NK细胞活性降低80 - 100%。由于许多前往癌症诊所的患者经常服用阿司匹林，因此，如果要将他们的细胞用于NK活性检测，必须询问他们近期该药物的使用情况。
