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Chemical structure and pharmacokinetics of 99mTc-labelled aminomethane diphosphonic acid derivatives.

作者信息

Unterspann S, Finck W

出版信息

Eur J Nucl Med. 1981;6(11):527-30. doi: 10.1007/BF00255886.

DOI:10.1007/BF00255886
PMID:7327190
Abstract

99mTc-labelled derivatives of aminomethane diphosphonic acid, general formula: R1R2N-CR3 [PO(OH)2]2, as well as hydroxyethane diphosphonic acid and hydroxypropane monophosphonic acid were investigated with regard to their suitability for skeleton scintigraphy. Bone accumulation was related to chemical structure. It was concluded from the experiments that compounds able to form enols are accumulated to a higher degree and that big substituents influence the affinity to bone negatively by steric hindrance.

摘要

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本文引用的文献

1
New bone scanning agent: 99m Tc-labeled 1-hydroxy-ethylidene-1, 1-disodium phosphonate.新型骨扫描剂：99m锝标记的1-羟基乙叉二膦酸二钠
J Nucl Med. 1972 Nov;13(11):823-7.
2
Method for the synthesis of 1-hydroxy-ethylidene-1, 1-disodium phosphonate (HEDSPA): a skeletal seeking radiopharmaceutical after labeling with 99mTc.1-羟基乙叉-1,1-二膦酸二钠（HEDSPA）的合成方法：一种用99mTc标记后用于骨显像的放射性药物。
J Nucl Med. 1974 Feb;15(2):127-30.
3
Technetium-99m-labeled stannous ethane-1-hydroxy-1 1-diphosphonate: a new bone scanning agent.
J Nucl Med. 1973 Feb;14(2):73-8.
4
Experimental examinations on the suitability of organoaminomethane-bis-phosphonic acids for bone-scintigraphy by means of Tc-99m in animals.
Eur J Nucl Med. 1976 Aug 12;1(3):151-4. doi: 10.1007/BF00257962.
5
Bone accumulation of the Tc-99m complex of carbamyl phosphate and its analogs.氨基甲酰磷酸及其类似物的Tc-99m络合物在骨骼中的蓄积。
J Nucl Med. 1978 May;19(5):530-3.
6
A study of the relationship between chemical structure and bone localization of Tc-99m diphosphonic acids: concise communication.锝-99m二膦酸盐的化学结构与骨定位关系的研究：简要通讯
J Nucl Med. 1979 Oct;20(10):1066-70.
7
Technetium-99m-methylene diphosphonate--a superior agent for skeletal imaging: comparison with other technetium complexes.锝-99m-亚甲基二膦酸盐——一种用于骨骼成像的优质试剂：与其他锝配合物的比较。
J Nucl Med. 1975 Aug;16(8):744-55.