外周血细胞比容调节慢性尿毒症患者促红细胞生成素的产生及网织红细胞的动力学。
Peripheral haematocrit modulates erythropoietin production and kinetics of reticulocytes in chronic uraemic patients.
作者信息
Walle A, Garcia J F, Niedermayer W
出版信息
Proc Eur Dial Transplant Assoc. 1981;18:633-7.
Determination of reticulocytes (RETI), haematocrit (HCT) and serum erythropoietin (by radioimmunoassay = EP-RIA) before and after transfusions of 500ml red blood cells (RBC) into 15 chronic uraemic patients demonstrated that there was a converse relation between both of these, EP-RIA and RETI, and the HCT. The same conditions were found in cases of spontaneous bleeding. This pattern of reaction of RETI, EP-RIA and HCT suggested a feedback circuit, operative between these three parameters in chronic uraemic patients.
对15名慢性尿毒症患者输注500毫升红细胞（RBC）前后的网织红细胞（RETI）、血细胞比容（HCT）和血清促红细胞生成素（通过放射免疫测定法=EP-RIA）进行测定，结果表明，EP-RIA和RETI与HCT之间存在相反的关系。在自发性出血的病例中也发现了相同的情况。RETI、EP-RIA和HCT的这种反应模式表明，在慢性尿毒症患者的这三个参数之间存在一个反馈回路。
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