佝偻病肠吸收细胞溶酶体的超微结构变化。

Ultrastructural changes in the lysosomes of rachitic intestinal absorptive cells.

作者信息

Jones R G, Davis W L

出版信息

Tissue Cell. 1981;13(4):739-46. doi: 10.1016/s0040-8166(81)80010-9.

Abstract

In chicks maintained on a rachitogenic (vitamin D deficient) diet, the number of intestinal absorptive cell calcium-lysosomes is markedly decreased in comparison to normal animals. In addition, the majority (better than 50%) of these rachitic calcium-lysosomes are atypical in their fine structure resembling the lamellar bodies seen in certain diseases (Tay-Sachs disease, Duchenne's muscular dystrophy). Such atypical organelles are characterized by their internal membranous swirls reminiscent of myelin figures. This information appears to be a further indication that lysosomes are normally involved in calcium homeostatic mechanisms and therefore sensitive to circulating vitamin D levels.

摘要

在以致佝偻病（维生素D缺乏）饮食喂养的雏鸡中，与正常动物相比，肠道吸收细胞钙溶酶体的数量明显减少。此外，这些佝偻病钙溶酶体中的大多数（超过50%）在精细结构上是非典型的，类似于某些疾病（泰-萨克斯病、杜兴氏肌营养不良症）中所见的板层小体。这种非典型细胞器的特征是其内部膜状漩涡让人联想到髓鞘结构。这一信息似乎进一步表明，溶酶体通常参与钙稳态机制，因此对循环中的维生素D水平敏感。