慢性脑脊膜神经根脊髓炎中寡克隆性、伯氏疏螺旋体特异性IgG的持续鞘内分泌
Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis.
作者信息
Martin R, Martens U, Sticht-Groh V, Dörries R, Krüger H
机构信息
Abteilung Neurologie, Universität Würzburg, Federal Republic of Germany.
出版信息
J Neurol. 1988 Mar;235(4):229-33. doi: 10.1007/BF00314352.
Abstract
In the cerebrospinal fluid IgG of five patients with lymphomeningoradiculitis (Bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. Most of these oligoclonal bands were specific for Borrelia burgdorferi. In patients suffering from chronic meningoradiculomyelitis, repeated CSF examination by this technique showed persistent secretion of identical IgG bands. Thus, the specific humoral immune response and the disease activity could be documented over the course of the disease.
摘要
通过免疫印迹技术研究了5例淋巴细胞性脑膜炎神经根炎（班沃思综合征）和神经根脊髓炎患者的脑脊液IgG，发现了寡克隆模式。这些寡克隆带大多对伯氏疏螺旋体具有特异性。在患有慢性脑膜神经根脊髓炎的患者中，通过该技术重复进行脑脊液检查显示相同IgG带持续分泌。因此，在疾病过程中可以记录到特异性体液免疫反应和疾病活动情况。
相似文献
1
Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis.慢性脑脊膜神经根脊髓炎中寡克隆性、伯氏疏螺旋体特异性IgG的持续鞘内分泌
J Neurol. 1988 Mar;235(4):229-33. doi: 10.1007/BF00314352.
2
Intrathecal synthesis of anti-Borrelia burgdorferi antibodies in neuroborreliosis: a study with special emphasis on oligoclonal IgM antibody bands.神经型莱姆病中鞘内抗伯氏疏螺旋体抗体的合成：一项特别关注寡克隆IgM抗体条带的研究
Scand J Immunol. 1993 Mar;37(3):369-76. doi: 10.1111/j.1365-3083.1993.tb02566.x.
3
Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in Lyme neuroborreliosis.莱姆病神经伯氏疏螺旋体病患者脑脊液中的寡克隆性伯氏疏螺旋体特异性IgG抗体
J Infect Dis. 1990 Jun;161(6):1194-202. doi: 10.1093/infdis/161.6.1194.
4
Intrathecal production of specific antibodies against Borrelia burgdorferi in patients with lymphocytic meningoradiculitis (Bannwarth's syndrome).淋巴细胞性脑膜炎神经根炎（班沃思综合征）患者鞘内产生抗伯氏疏螺旋体的特异性抗体。
J Infect Dis. 1986 Feb;153(2):304-14. doi: 10.1093/infdis/153.2.304.
5
Immunoglobulin abnormalities in cerebrospinal fluid and blood over the course of lymphocytic meningoradiculitis (Bannwarth's syndrome).淋巴细胞性脑膜炎神经根炎（班沃特氏综合征）病程中脑脊液和血液中的免疫球蛋白异常。
Ann Neurol. 1986 Sep;20(3):337-45. doi: 10.1002/ana.410200311.
6
Lyme arthritis: oligoclonal anti-Borrelia burgdorferi IgG antibodies occur in joint fluid and serum.莱姆关节炎：关节液和血清中出现寡克隆抗伯氏疏螺旋体IgG抗体。
Scand J Immunol. 1991 Jan;33(1):61-71. doi: 10.1111/j.1365-3083.1991.tb02492.x.
7
Bannwarth's syndrome: serum and CSF IgG antibodies against Borrelia burgdorferi examined by ELISA.班诺瓦特综合征：通过酶联免疫吸附测定法检测血清和脑脊液中抗伯氏疏螺旋体的IgG抗体。
Acta Neurol Scand. 1987 Jan;75(1):37-45. doi: 10.1111/j.1600-0404.1987.tb07886.x.
8
Measurement of antibodies to the Borrelia burgdorferi flagellum improves serodiagnosis in Lyme disease.检测抗伯氏疏螺旋体鞭毛抗体可改善莱姆病的血清学诊断。
J Clin Microbiol. 1988 Feb;26(2):338-46. doi: 10.1128/jcm.26.2.338-346.1988.
9
Serological diagnosis of Borrelia meningitis.莱姆病脑膜炎的血清学诊断。
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Feb;263(3):420-4. doi: 10.1016/s0176-6724(87)80102-5.
10
Enzyme-linked immunosorbent assays for the detection of class-specific immunoglobulins to Borrelia burgdorferi.用于检测针对伯氏疏螺旋体的类特异性免疫球蛋白的酶联免疫吸附测定。
Am J Epidemiol. 1988 Apr;127(4):818-25. doi: 10.1093/oxfordjournals.aje.a114864.
引用本文的文献
1
Case Report: Para-infectious cranial nerve palsy after bacterial meningitis.病例报告：细菌性脑膜炎后继发性感染性颅神经麻痹。
Front Immunol. 2022 Oct 6;13:1000912. doi: 10.3389/fimmu.2022.1000912. eCollection 2022.
2
The Role of Herpes Simplex Virus Type 1 Infection in Demyelination of the Central Nervous System.单纯疱疹病毒 1 型感染在中枢神经系统脱髓鞘中的作用。
Int J Mol Sci. 2020 Jul 16;21(14):5026. doi: 10.3390/ijms21145026.
3
Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins.多发性硬化症中不同的寡克隆带抗体识别普遍存在的自身蛋白。
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7864-9. doi: 10.1073/pnas.1522730113. Epub 2016 Jun 20.
4
Laboratory diagnosis of Lyme disease: advances and challenges.莱姆病的实验室诊断：进展与挑战
Infect Dis Clin North Am. 2015 Jun;29(2):295-307. doi: 10.1016/j.idc.2015.02.005.
5
Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosis.病原体特异性和自身免疫是神经莱姆病中抗原驱动免疫反应的不同特征。
Infect Immun. 2007 Aug;75(8):3842-7. doi: 10.1128/IAI.00260-07. Epub 2007 May 21.
6
Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodies.对亚急性硬化性全脑炎大脑中的浆细胞进行激光捕获显微切割，发现鞘内存在与疾病相关的抗体。
Proc Natl Acad Sci U S A. 2005 May 17;102(20):7245-50. doi: 10.1073/pnas.0502323102. Epub 2005 May 9.
7
Variable CSF findings in early and late Lyme neuroborreliosis: a follow-up study in 47 patients.早期和晚期莱姆病神经伯氏疏螺旋体病脑脊液的可变表现：47例患者的随访研究
J Neurol. 1994 Dec;242(1):26-36. doi: 10.1007/BF00920571.
8
Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a follow-up study of 72 patients over 27 years.伯氏疏螺旋体所致脑脊神经根炎和脑脊髓炎：27年间72例患者的随访研究
J Neurol. 1989 Sep;236(6):322-8. doi: 10.1007/BF00314373.
9
Treatment of Lyme borreliosis. Randomized comparison of doxycycline and penicillin G.
J Neurol. 1989 Dec;236(8):464-9. doi: 10.1007/BF00328508.
10
Intrathecal synthesis of virus-specific oligoclonal antibodies in patients with enterovirus infection of the central nervous system.中枢神经系统肠道病毒感染患者鞘内病毒特异性寡克隆抗体的合成
J Neurol. 1989 Oct;236(7):395-9. doi: 10.1007/BF00314897.
本文引用的文献
1
Viral antibodies in oligoclonal and polyclonal IgG synthesized within the central nervous system over the course of mumps meningitis.腮腺炎脑膜炎病程中在中枢神经系统内合成的寡克隆和多克隆IgG中的病毒抗体。
J Neuroimmunol. 1981 Sep;1(3):287-98. doi: 10.1016/0165-5728(81)90032-1.
2
Mumps meningitis: specific and non-specific antibody responses in the central nervous system.腮腺炎脑膜炎：中枢神经系统中的特异性和非特异性抗体反应
Acta Neurol Scand. 1982 May;65(5):468-87. doi: 10.1111/j.1600-0404.1982.tb03104.x.
3
Lyme disease-a tick-borne spirochetosis?莱姆病——一种蜱传播的螺旋体病？
Science. 1982 Jun 18;216(4552):1317-9. doi: 10.1126/science.7043737.
4
Neurosyphilis: intrathecal synthesis of oligoclonal antibodies to Treponema pallidum.神经梅毒：针对梅毒螺旋体的寡克隆抗体的鞘内合成。
Ann Neurol. 1982 Jan;11(1):35-40. doi: 10.1002/ana.410110107.
5
Characterization of antibody activity in oligoclonal immunoglobulin G synthesized within the central nervous system in a patient with tuberculous meningitis.结核性脑膜炎患者中枢神经系统内合成的寡克隆免疫球蛋白G中抗体活性的特征分析。
J Clin Microbiol. 1981 Jan;13(1):30-5. doi: 10.1128/jcm.13.1.30-35.1981.
6
Lyme disease.莱姆病
Am J Dis Child. 1984 May;138(5):467-70. doi: 10.1001/archpedi.1984.02140430045011.
7
Detection and identification of virus-specific, oligoclonal IgG in unconcentrated cerebrospinal fluid by immunoblot technique.通过免疫印迹技术检测和鉴定未浓缩脑脊液中病毒特异性寡克隆IgG。
J Neuroimmunol. 1984 Dec;7(2-3):77-89. doi: 10.1016/s0165-5728(84)80008-9.
8
Comparison of an indirect fluorescent-antibody test with an enzyme-linked immunosorbent assay for serological studies of Lyme disease.用于莱姆病血清学研究的间接荧光抗体试验与酶联免疫吸附测定的比较。
J Clin Microbiol. 1984 Aug;20(2):181-4. doi: 10.1128/jcm.20.2.181-184.1984.
9
Antibody response in Lyme disease: evaluation of diagnostic tests.莱姆病中的抗体反应：诊断测试评估
J Infect Dis. 1984 May;149(5):789-95. doi: 10.1093/infdis/149.5.789.
10
Lyme disease.莱姆病
Am J Med. 1983 Oct;75(4):663-70. doi: 10.1016/0002-9343(83)90454-0.
Zotero 插件