Fischler M, Geschwind H, Ducimetière P, Vahanian A, Usdin J P, Laurent D
Ann Med Interne (Paris). 1981;132(8):544-50.
To determine the relationship between functional classes (NYHA) and hemodynamics in patients (pts) with chronic aortic insufficiency, indices of left ventricular (LV) function derived from hemodynamic and biplane left cineventriculographic data were compared with the clinical status in 51 AI pts, including 15 pts in class I, 26 pts in class II and 10 pts in class III. Regurgitant fraction (0.55 +/- 0.15 mean +/- SD), cardiac index (3.1 +/- 0.7 l/mn/m2) and LV end-diastolic pressure (14 +/- 7 mmHg) were of the same order of magnitude in 3 classes patients. A significant correlation was evidenced between functional classes and 1/LV ejection fraction (0.53 +/- 0.13, 0.50 +/- 0.39, 0.42 +/- 0.17 in class I, II, III pts, respectively, p less than 0.04), 2/LV end-systolic volume (88 +/- 48, 90 +/- 31, 138 +/- 68 ml/m2 in class I, II and III pts, respectively p less than 0.02), 3/ and LV mass (168 +/- 57, 204 +/- 94, 291 +/- 128 g/m2 in class I, II and III pts respectively, p less than 0.003). Only the latter parameter could discriminate symptomatic from asymptomatic AI pts.
为了确定慢性主动脉瓣关闭不全患者（pts）的心功能分级（纽约心脏协会分级，NYHA）与血流动力学之间的关系，我们将从血流动力学和双平面左心室造影数据得出的左心室（LV）功能指标，与51例主动脉瓣关闭不全患者的临床状况进行了比较，其中包括15例I级患者、26例II级患者和10例III级患者。反流分数（平均±标准差为0.55±0.15）、心脏指数（3.1±0.7 l/分钟/平方米）和左心室舒张末期压力（14±7 mmHg）在这3组患者中处于同一数量级。心功能分级与以下指标之间存在显著相关性：1/左心室射血分数的倒数（I级、II级、III级患者分别为0.53±0.13、0.50±0.39、0.42±0.17，p<0.04）；2/左心室收缩末期容积（I级、II级、III级患者分别为88±48、90±31、138±68 ml/平方米，p<0.02）；3/左心室质量（I级、II级、III级患者分别为168±57、204±94、291±128 g/平方米，p<0.003）。只有后一个参数能够区分有症状和无症状的主动脉瓣关闭不全患者。
