Cornelio F, Di Donato S, Testa D, Mora M, Gori G, Peluchetti D, Rimoldi M
Ital J Neurol Sci. 1980 Mar;1(2):95-100.
A 13-year-old boy with a mild limb girdle muscular weakness had a massive rhabdomyolysis and cardiac arrest after general anesthesia. A congestive cardiomyopathy then developed. Muscle biopsy revealed an unspecific "myopathic" degeneration of muscle fibers and a slight accumulation of lipid droplets. Carnitine content was markedly reduced in muscle and moderately in plasma. Both prednisone and carnitine therapies were unable to improve the heart insufficiency, and the patient died 1 year after the acute episode of rhabdomyolysis.
一名患有轻度肢带型肌无力的13岁男孩在全身麻醉后发生了大面积横纹肌溶解和心脏骤停。随后出现了充血性心肌病。肌肉活检显示肌纤维有非特异性的“肌病性”变性以及脂滴轻度积聚。肌肉中的肉碱含量显著降低，血浆中的含量中度降低。泼尼松和肉碱治疗均未能改善心脏功能不全，该患者在横纹肌溶解急性发作1年后死亡。
