Potgieter L N, Jones J B, Patton C S, Webb-Martin T A
Can J Comp Med. 1981 Jul;45(3):212-6.
Five eight week old dogs were inoculated orally and intranasally with cell culture origin canine parvovirus. Three dogs became depressed and anorectic and developed a mild (one dog) to severe diarrhea five days postinfection. The remaining dogs had subclinical infections but developed a lymphopenia followed by a transient lymphocytosis. The ill dogs developed mild (one dog) to severe neutropenia and a moderate lymphopenia. One died nine days postinfection. Recovery was associated with cessation of viral excretion and with lymphocytosis and antibody production. Two of three dogs challenged intragastrically developed mild clinical signs and a moderate panleukopenia four to eight days postinfection. The pathological changes of the experimental disease were very similar to that of spontaneous disease. Bone marrow changes included a severe granulocytic and mild erythroid depletion. The pathogenesis of canine parvovirus infection is discussed.
五只八周龄的狗经口服和鼻内接种细胞培养来源的犬细小病毒。三只狗在感染后五天变得抑郁、厌食，并出现了轻度（一只狗）至重度腹泻。其余的狗有亚临床感染，但出现了淋巴细胞减少，随后是短暂的淋巴细胞增多。患病的狗出现了轻度（一只狗）至重度中性粒细胞减少和中度淋巴细胞减少。一只在感染后九天死亡。恢复与病毒排泄停止、淋巴细胞增多和抗体产生有关。三只经胃内攻击的狗中有两只在感染后四至八天出现了轻度临床症状和中度全血细胞减少。实验性疾病的病理变化与自发性疾病非常相似。骨髓变化包括严重的粒细胞减少和轻度的红细胞减少。本文讨论了犬细小病毒感染的发病机制。
