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乙胺丁醇对耻垢分枝杆菌磷脂代谢的影响。

Effects of ethambutol on phospholipid metabolism in Mycobacterium smegmatis.

作者信息

Kilburn J O, Takayama K, Armstrong E L, Greenberg J

出版信息

Antimicrob Agents Chemother. 1981 Feb;19(2):346-8. doi: 10.1128/AAC.19.2.346.

DOI:10.1128/AAC.19.2.346
PMID:7347565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC181426/
Abstract

Soon after Mycobacterium smegmatis was exposed to ethambutol, the synthesis of cardiolipin and phosphatidylinositol dimannoside declined. The synthesis of phosphatidylethanolamine continued, but the drug caused this phospholipid to leak out of the cells.

摘要

耻垢分枝杆菌暴露于乙胺丁醇后不久，心磷脂和磷脂酰肌醇二甘露糖苷的合成减少。磷脂酰乙醇胺的合成仍在继续，但该药物导致这种磷脂从细胞中泄漏出来。

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本文引用的文献

1
A SIMPLE, SPECIFIC SPRAY FOR THE DETECTION OF PHOSPHOLIPIDS ON THIN-LAYER CHROMATOGRAMS.一种用于检测薄层色谱图上磷脂的简单、特效喷雾剂。
J Lipid Res. 1964 Jan;5:126-7.
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Effect of ethambutol on the viable cell count in Mycobacterium smegmatis.乙胺丁醇对耻垢分枝杆菌活菌数的影响。
Antimicrob Agents Chemother. 1977 Mar;11(3):534-40. doi: 10.1128/AAC.11.3.534.
3
Inhibition by ethambutol of mycolic acid transfer into the cell wall of Mycobacterium smegmatis.乙胺丁醇对分枝菌酸转运至耻垢分枝杆菌细胞壁的抑制作用。
Antimicrob Agents Chemother. 1979 Aug;16(2):240-2. doi: 10.1128/AAC.16.2.240.
4
Secretion of lipids induced by inhibition of peptidoglycan synthesis in streptococci.抑制链球菌中肽聚糖合成所诱导的脂质分泌。
J Bacteriol. 1977 Nov;132(2):704-17. doi: 10.1128/jb.132.2.704-717.1977.