Silve G, Valero-Guillen P, Quemard A, Dupont M A, Daffe M, Laneelle G
Département des Glycoconjugués et Biomembranes, Centre National de la Recherche Scientifique, Toulouse, France.
Antimicrob Agents Chemother. 1993 Jul;37(7):1536-8. doi: 10.1128/AAC.37.7.1536.
The addition of D-arabinose, D-galactose, D-glucosamine, or D-mannose to the growth medium of Mycobacterium smegmatis suppressed the inhibitory effects of ethambutol both on acetate labeling of cell wall-linked mycolic acids and on the increase in the delipidated cell dry weight. The addition of D-glucose or D-fructose had no effect. It is proposed that ethambutol inhibits an early step of glucose conversion into the monosaccharides used for the biosynthesis of structurally and biologically important cell wall polysaccharides: arabinogalactan, arabinomannan, and peptidoglycan.
在耻垢分枝杆菌的生长培养基中添加D-阿拉伯糖、D-半乳糖、D-葡萄糖胺或D-甘露糖，可抑制乙胺丁醇对细胞壁连接的分枝菌酸乙酸盐标记以及脱脂细胞干重增加的抑制作用。添加D-葡萄糖或D-果糖则没有效果。有人提出，乙胺丁醇抑制了葡萄糖转化为用于生物合成结构和生物学上重要的细胞壁多糖（阿拉伯半乳聚糖、阿拉伯甘露聚糖和肽聚糖）的单糖的早期步骤。
