Uchihara T, Kondo H, Ikeda K, Kosaka K
Department of Neuropathology, Tokyo Institute of Psychiatry, Japan.
J Neurol. 1995 Aug;242(8):485-9. doi: 10.1007/BF00867417.
Bleaching of melanin prior to Gallyas staining enabled us to detect an unexpectedly large number of neurofibrillary tangles (NFTs; 62 and 50 NFTs in the upper and the lower substantia nigra, respectively, mostly in the neuronal cytoplasm of the medial zona compacta) in brains of patients who had had Alzheimer's disease. Amyloid-like deposits were quite scarce. In Alzheimer's disease it has been commonly observed that other subcortical nuclei projecting widely to the cerebral cortex also contain a large number of NFTs, although they have few amyloid deposits. In these subcortical nuclei retrograde degeneration may initially affect intraneuronal processes, leading to the preferential development of NFTs in the neuronal cytoplasm.
在进行加利亚斯染色之前对黑色素进行漂白，使我们能够在患有阿尔茨海默病的患者大脑中检测到数量出乎意料的神经原纤维缠结（NFTs；分别在黑质上部和下部有62个和50个NFTs，大多位于致密带内侧的神经元胞质中）。淀粉样沉积物相当稀少。在阿尔茨海默病中，通常观察到其他广泛投射到大脑皮层的皮质下核也含有大量NFTs，尽管它们的淀粉样沉积物很少。在这些皮质下核中，逆行性变性最初可能影响神经元内的突起，导致NFTs在神经元胞质中优先发展。
