Stuss D T, Benson D F, Kaplan E F, Weir W S, Della Malva C
Biol Psychiatry. 1981 Nov;16(11):1085-100.
Deficits in attention have been strongly linked with both schizophrenia and pathology in the prefrontal cortex. This observation was tested by administering a battery of commonly used tests of attention, sustained mental activity, and tracking to 16 patients who had undergone prefrontal leucotomy approximately 25 years earlier. Presurgical diagnosis in each patient was schizophrenia. The 16 were divided into three groups based on their recovery after surgery. A control group of nonleucotomized schizophrenics was established to control for psychiatric symptomatology. A second control group consisted of subjects without history of psychiatric or CNS disorder. In general, there was no statistically significant impairment of performance in attention tests between the patients with prefrontal psychosurgery and the normal control subjects. The nonoperated schizophrenic control group performed most poorly. Lesion chronicity, interaction of leucotomy and presurgical psychiatric state, and conditions of test administration are suggested as possible explanations for the unexpected results.
注意力缺陷与精神分裂症以及前额叶皮质病变都有着密切联系。通过对大约25年前接受过前额叶白质切除术的16名患者进行一系列常用的注意力、持续精神活动和追踪测试，对这一观察结果进行了验证。每位患者术前诊断均为精神分裂症。根据术后恢复情况，将这16名患者分为三组。设立了一个未接受白质切除术的精神分裂症患者对照组，以控制精神症状。第二个对照组由无精神病史或中枢神经系统疾病史的受试者组成。总体而言，接受前额叶精神外科手术的患者与正常对照组在注意力测试中的表现没有统计学上的显著损害。未接受手术的精神分裂症对照组表现最差。病变的慢性程度、白质切除术与术前精神状态的相互作用以及测试实施条件被认为是导致这些意外结果的可能原因。
